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Report Overview

The United States glucagon-like peptide-1 (GLP-1) agonists market was valued at USD 10.25 Billion in 2024, driven by the rising prevalence of type 2 diabetes and obesity along with the robust regulatory support in the region. The market is anticipated to grow at a CAGR of 8.20% during the forecast period of 2025-2034, with the values likely to reach USD 22.54 Billion by 2034.

2024

Base Year

2018-2024

Historical Period

2025-2034

Forecast Period

  • About 1 in 10 people in the United States are living with diabetes, with 90% to 95% of them having type 2 diabetes. The rising prevalence of diabetes in the region is expected to boost the market demand in the forecast period.

  • The increasing expansion of GLP-1 therapies into new indications and rising consumer awareness are projected to elevate the United States glucagon-like peptide-1 (GLP-1) agonists market value.

  • In December 2024, the FDA approved a generic version of liraglutide (Victoza) for type 2 diabetes, following a generic exenatide (Byetta) approval in November. The rising generic GLP-1 approvals are a major market trend.

Compound Annual Growth Rate

Value in USD Billion

8.2%

2025-2034


United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Outlook

*this image is indicative*

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Overview

The United States is considered the largest and fastest-growing market for glucagon-like peptide-1 (GLP-1) receptor agonists, owing to the rising prevalence of obesity and type 2 diabetes. The increasing demand for advanced weight loss and diabetes treatments is making GLP-1 drugs like Ozempic, Wegovy, and Mounjaro popular among both patients and healthcare providers. The growing regulatory approval for new GLP-1-based drugs is a significant market trend. Additionally, the expanding clinical trials and increasing insurance coverage are poised to boost market growth over the forecast period.

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Growth Drivers

Rising Prevalence of Diabetes to Support Market Growth

According to the Centers for Disease Control and Prevention (CDC), about 1 in 10 people in the United States are affected by diabetes, accounting for more than 38 million Americans. It is also reported that 90% to 95% of them suffer from type 2 diabetes. The rising diabetes cases are increasing demand for GLP-1 receptor agonists like Ozempic and Mounjaro. Moreover, ongoing drug innovation and rising investments are expected to further expedite the market growth.

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Trends

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Segmentation

The market report offers a detailed analysis of the market based on the following segments:

Market Breakup by Drugs

  • Dulaglutide
  • Exenatide
  • Liraglutide
  • Tirzepatide
  • Lixisenatide
  • Semaglutide

Market Breakup by Application

  • Type 2 Diabetes Mellitus
  • Obesity

Market Breakup by Route of Administration

  • Parenteral
  • Oral

Market Breakup by End User

  • Hospitals
  • Specialty Clinics
  • Academic and Research Institutes
  • Others

Market Breakup by Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Share

Segmentation Based on Drugs to Witness Substantial Growth

Based on the drugs, the United States market is segmented into dulaglutide, exenatide, liraglutide, tirzepatide, lixisenatide, and semaglutide. Semaglutide holds a significant market share due to its established efficacy and availability of multiple formulations (Ozempic, Wegovy, Rybelsus). On the other hand, dulaglutide is a once-weekly injectable GLP-1 agonist used for type 2 diabetes management. It remains a popular alternative due to its convenience and cardiovascular benefits.

United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Analysis by Region

In the United States, the Northeast and West Coast regions have high adoption rates as a result of better healthcare access and widespread insurance coverage for GLP-1 drugs like Ozempic, Wegovy, and Mounjaro. The Midwest and Southern states are witnessing substantial obesity and type 2 diabetes rates, which is fuelling the market demand in the region. Further, the expansion of pharmaceutical manufacturing facilities in states like North Carolina and Indiana is anticipated to address GLP-1 drug shortages and elevate the market value.

Leading Players in the United States Glucagon-like Peptide-1 (GLP-1) Agonists Market

The key features of the market report comprise patent analysis, grants analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:

Eli Lilly and Company

Eli Lilly is rapidly expanding its share in the United States market for GLP-1, with Mounjaro (tirzepatide) witnessing high demand for both diabetes and weight management. The company is investing substantially in new manufacturing plants in the region to scale up production and address ongoing GLP-1 drug shortages.

Sanofi

Sanofi is strategically strengthening its presence in the United States glucagon-like peptide-1 (GLP-1) agonists market, focusing on partnerships and pipeline expansion to compete with other key players like Novo Nordisk and Eli Lilly. The company is investing in R&D to develop novel GLP-1 formulations, particularly in once-weekly and oral therapies.

Novo Nordisk A/S

Novo Nordisk is one of the dominating players in the market, with Wegovy and Ozempic experiencing growing demand. To address drug shortages, the company is expanding production facilities and exploring additional supply chain improvements. Novo Nordisk is also partnering with U.S. healthcare providers to increase awareness and accessibility of GLP-1 therapies for obesity treatment.

AstraZeneca plc

AstraZeneca is shifting focus toward GLP-1 combination therapies in the United States, aiming to integrate GLP-1 drugs with cardiovascular and kidney disease treatments. The company is conducting new clinical trials on dual-action metabolic drugs that could complement GLP-1 receptor agonists.

*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*

Other key players in the market include Pfizer Inc., Boehringer Ingelheim, F. Hoffmann-La Roche, Amgen Inc., and GlaxoSmithKline plc.

Key Questions Answered in the United States Glucagon-like Peptide-1 (GLP-1) Agonists Market Report

  • What was the United States glucagon-like peptide-1 (GLP-1) agonists market value in 2024?
  • What is the United States glucagon-like peptide-1 (GLP-1) agonists market forecast outlook for 2025-2034?
  • What is the market segmentation based on drugs?
  • What is the market segmentation based on application?
  • What is the market breakup based on the route of administration?
  • What is the market breakup by end user?
  • What is the market breakup based on the distribution channel?
  • What major factors aid the United States glucagon-like peptide-1 (GLP-1) agonists market demand?
  • How has the market performed so far and how is it anticipated to perform in the coming years?
  • What are the major drivers, opportunities, and restraints in the market?
  • What are the major trends influencing the market?
  • Who are the key players involved in the United States glucagon-like peptide-1 (GLP-1) agonists market?
  • What are the current unmet needs and challenges in the market?
  • How are partnerships, collaborations, mergers, and acquisitions among the key market players shaping the market dynamics?

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

REPORT FEATURES DETAILS
Base Year 2024
Historical Period 2018-2024
Forecast Period 2025-2034
Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:

  • Drugs
  • Application
  • Route of Administration
  • End User
Breakup by Drugs
  • Dulaglutide
  • Exenatide
  • Liraglutide
  • Tirzepatide
  • Lixisenatide
  • Semaglutide
Breakup by Application
  • Type 2 Diabetes Mellitus
  • Obesity
Breakup by Route of Administration
  • Parenteral
  • Oral
Breakup by End User
  • Hospitals
  • Specialty Clinics
  • Academic and Research Institutes
  • Others
Breakup by Distribution Channel
  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies
Market Dynamics
  • SWOT Analysis
  • Porter's Five Forces Analysis
  • Key Indicators for Demand
  • Key Indicators for Price
Competitive Landscape
  • Market Structure
  • Company Profiles
    • Company Overview
    • Product Portfolio
    • Demographic Reach and Achievements
    • Certifications
Companies Covered
  • Eli Lilly and Company
  • Sanofi
  • Novo Nordisk A/S
  • AstraZeneca plc
  • Pfizer Inc.
  • Boehringer Ingelheim
  • F. Hoffmann-La Roche
  • Amgen Inc.
  • GlaxoSmithKline plc

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