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The global nucleic acid therapeutics market was valued at USD 4.81 Billion in 2025. It is projected to grow at a CAGR of 12.84% during the forecast period of 2026-2035 and attain a market value of USD 16.10 Billion by 2035. Advancements in oligonucleotide design, RNA delivery systems, and increasing approvals for nucleic acid-based drugs drive the market growth. Expanding applications in oncology, infectious diseases, and rare genetic disorders further support market growth. However, high manufacturing costs and complex regulatory pathways may challenge adoption during the forecast period.
Base Year
Historical Period
Forecast Period
The rising incidences of genetic disorders and other chronic diseases, including cystic fibrosis, muscular dystrophy, cancer, and heart diseases, are fueling the growth of the market.
In August 2023, CureVac N. V. and GSK launched a phase II trial for monovalent and bivalent COVID-19 vaccines based on mRNA. This shows ongoing research, development, and investment in markets and the development of nucleic acid based medications.
In August 2023, CureVac N. V. and GSK launched a phase II trial for monovalent and bivalent COVID-19 vaccines based on mRNA. This shows ongoing research, development, and investment in markets and the development of nucleic acid based medications.
Compound Annual Growth Rate
12.84%
Value in USD Billion
2026-2035
*this image is indicative*
Nucleic acid therapeutics utilize either synthetic or natural nucleic acids to control gene expression and address multiple ailments. ASOs, siRNAs, miRNAs, aptamers, and CRISPR/Cas9 are some of the common technologies used in this treatment. They provide a focused method for managing diseases, enabling accurate genetic intervention, particularly helpful for diseases with identifiable genetic causes like rare genetic disorders, cancers, and viral infections.
Increasing Prevalence of Genetic Disorders and Chronic Diseases Boost the Market Growth
The rising prevalence of genetic disorders, and other diseases, such as cystic fibrosis, muscular dystrophy, cancer, cardiovascular diseases, metabolic syndrome, and others are the primary factors boosting the market growth. Aberrations of DNA sequences and gene expression are often observed in these indications, for which nucleic acid therapies are a suitable solution, providing effective treatment to a wider section of the population. This is leading to an increased application of nucleic acid therapeutics, intended to combat the burden of rising morbidities.
Advancements in Genomic Technologies and Personalized Medicine to Meet Rising Nucleic Acid Therapeutics Market Demand
Advanced technologies in nucleic acid therapeutics include NGS, CRISPR/Cas9 gene editing, and bioinformatics which has further advanced the progress of these therapeutics. This makes it easier to diagnose the mutation in genes and get the right treatment for the individuals affected. The market growth is driven by the increasing demand for personalized treatments, where treatments and medications are based on a person’s genetic profile.
Increase in Clinical Trial and Research Initiatives
In August 2023, CureVac N.V. and GSK initiated a Phase 2 trial in Australia for their single and double-modified mRNA COVID-19 vaccine candidates. The study's goal is to evaluate the safety, reactogenicity, and immune responses in 415 healthy adults after successful Phase 1 results for a comparable vaccine designed for the omicron BA.1 variant.
In March 2022, Moderna, Inc. tested an experimental HIV trimer mRNA vaccine (mRNA-1574) in around 100 HIV-negative adults in a Phase 1 clinical trial. The NIAID-sponsored trial within the NIH aimed to evaluate the safety and immunogenicity of the vaccine. An NIAID grant funded the development of the vaccine, with assistance from Scripps Research and IAVI.
Several trends and developments are being observed in the market to enhance the current situation. Some of the noteworthy trends are as follows:
Nucleic Acid Therapeutics Market Report and Forecast 2026-2035 offers a detailed analysis of the market based on the following segments:
Market Breakup by Product Type
Market by Indication
Market Breakup by End User
Market Breakup by Region
Market Segmentation Based on End User Set to Witness Substantial Growth
Based on the end user, the market is divided into hospitals, research and academic institutes, and others. Among these, the market is expected to be dominated by research laboratories due to the rising demand for nucleic acid research and treatment interventions. These labs discover new medications and technologies, thereby nurturing new ideas for broadening their applications. Due to the tremendous interest in genetics and molecular targeted therapies, more research institutes and biotechnology companies are anticipated to adopt these technologies and impact the market landscape significantly.
Based on regions, the market report covers North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa. North America is expected to dominate the market, driven by an immense focus on providing investments to conduct research. In addition, the presence of technically advanced infrastructure also impacts the market value positively.
European nucleic acid market comes next as a region with high regard for innovation, and noteworthy support from the healthcare regulatory authorities, aiding the implementation of neurotechnology. Growth in developing countries, especially in Asia Pacific, due to economic development, higher healthcare expenditure, and a rising population of patients suffering from genetic and chronic diseases, is encouraging market growth.
The key features of the market report include patent analysis, clinical trials analysis, grants analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies are:
Established in 1995 and headquartered in Ticino, Switzerland, the company has a diversified product line concerning nucleic acid therapeutics. This clinical stage biopharmaceutical company has a key emphasis on leveraging gene therapy to treat rare diseases.
Founded in 1994, the company has a presence across the United States, United Kingdom and other parts of Europe. The company is building a robust siRNAs-based pipeline for various diseases including rare diseases like Polycythemia Vera (PV) and other cardiovascular diseases. It is focused on using its mRNAi GOLD™ platform to develop innovative technologies for precise drug development.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other companies include Sanofi S.A., Thermo Fisher Scientific Inc., Sarepta Therapeutics, Inc., Novartis AG, Merck & Co., Inc., Alnylam Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and Arrowhead Pharmaceuticals, Inc.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Product Type |
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| Breakup by Indication |
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| Breakup by End User |
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| Breakup by Region |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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