Global Knee Cartilage Repair Market Report and Forecast 2024-2032

Global Knee Cartilage Repair Market Outlook

The global knee cartilage repair market size attained a value of about USD 2.99 billion in 2023, driven by the rising demand of minimally invasive knee surgeries across the globe. The market value is anticipated to grow at a CAGR of 6.2% during the forecast period of 2024-2032 to attain a market value of USD 5.15 billion by 2032.

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Global Knee Cartilage Repair Market Likely to be Driven by Demand for Treatment Options for Rising Instances of Knee Problems

In orthopaedics, articular cartilage injuries are a serious clinical concern. With high incidence of injury and limited intrinsic tissue repair potential, a large population of youthful and healthy individuals are left in danger of developing degenerative osteoarthritis (OA). It is estimated that over 30% of Americans above 45 years of age experience some type of knee pain.

Cartilage is a type of connective tissue found in several parts of the body. It is relatively easy to damage, despite being a robust and flexible material.

Chondral lesions are a common occurrence in a significant majority of the population. Chondroplasty is a common procedure performed to treat chondral injuries. It involves the removal of damaged tissue. While this approach offers symptomatic relief in the short-run, the remaining tissue becomes more prone to deterioration and faster degeneration.

Microfracture, which entails piercing the subchondral bone to enable the bone marrow to plug the defect, is another prevalent procedure. However, it leads to the creation of mechanically inferior fibrocartilage tissue.

Mosaicplasty, also known as osteochondral autologous transplantation (OATs), is an open treatment that involves harvesting osteochondral plugs from non-weight-bearing areas and transplanting them into the deficiency. However, transplanted cartilage has been shown to produce donor site morbidity; it does not combine well with existing cartilage, and degenerates with time.

Modern cartilage regeneration techniques include autologous chondrocyte implantation (ACI), matrix-associated autologous chondrocyte implantation (MACI), and autologous matrix-induced chondrogenesis (AMIC).

In the MACI technique, a two-stage procedure is followed. It is an advancement of the ACI approach. Healthy cartilage cells are extracted from the patient, then expanded and seeded in a collagen matrix; these are then re-implanted into the cartilage defect.

AMIC is a single-stage treatment that involves implanting a cell-free collagen matrix into a cartilage defect and then microfracturing it.

While these treatment options have provided better outcomes than conventional techniques such as chondroplasty and microfracture, they largely remain limited to a minority of the patient population with close to ideal surgical conditions. Such patients are most likely to benefit significantly after an intervention. The larger population with more severe symptoms, or those who suffer from co-morbidities precluding them from these cartilage repair interventions are limited to short-term palliative treatment alternatives, such as oral non-steroidal anti-inflammatory drugs (NSAIDs) or intra-articular injections of corticosteroids or hyaluronic acid. Although these treatments offer short-term relief from pain and inflammation, the long-term solution for such patients seems to be total joint replacement.

Innovative Solutions by Leading Companies Expected to Stimulate the Market

Several leading companies such as Stryker Corporation, Smith and Nephew, Vericel Corporation are engaged in providing treatment solutions for joint problems. In 2017, Vericel Corporation announced the first MACI implant in USA to repair symptomatic single or multiple full-thickness cartilage defects of the knee with or without bone involvement in adults. Smith and Nehphew offer CARGEL Bioscaffold - an easy, ready-to-use product employed in a single-step bone marrow stimulation procedure to provide superior cartilage repair. Stryker Corporation introduced a cementless total knee system - cementless total knee arthroplasty (TKA) with Triathlon Tritanium – that is becoming quite popular. The system has been reported to deliver good clinical outcomes and significant pain reduction. Such advancements in treatment systems are expected to boost the market. North America, Europe and Asia Pacific are expected to be key markets.

Global Knee Cartilage Repair Market Segmentation

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By modality, the market is segmented into:

• Cell-Based (further broken down by type as given below)
  • Chondrocyte Transplantation
  • Growth Factor Technology
• Non-Cell Based (further broken down by type as given below)
  • Tissue Scaffolds
  • Cell-Free Composites

By treatment type, the market is classified into:

• Palliative (further broken down by type as given below)
  • Viscosupplementation
  • Debridement and Lavage
• Intrinsic Repair Stimulus

By end-user, the market is divided into:

• Hospitals 
• Ambulatory Surgical Centers
• Orthopaedic Clinics
• Others

By region, the market is segmented into:

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa

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Key Industry Players in the Global Knee Cartilage Repair Market

The report presents a detailed analysis of the following key players in the market, looking into their capacity, and latest developments like capacity expansions, plant turnarounds, and mergers and acquisitions:

• Stryker
• Zimmer Biomet
• B. Braun Melsungen AG
• The Future of Biotechnology
• MEDIPOST
• Vericel Corporation
• CONMED Corporation
• Meril Life Sciences Pvt. Ltd.
• Medacta International
• Teijin Nakashima Medical Co., Ltd.
• EVOLUTIS INDIA PVT. LTD.
• Regentis Biomaterials Ltd.
• Auxein Medical.

The EMR report gives an in-depth insight into the industry by providing a SWOT analysis as well as an analysis of Porter’s Five Forces model.

Key Highlights of the Report