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The ischemia reperfusion injury therapeutics market size was valued at USD 1.67 billion in 2023, driven by the prevalence of chronic diseases in a geriatric population across the globe. The market is expected to grow at a CAGR of 4.6% during the forecast period of 2024-2032, with the values likely to rise from USD 1.75 billion in 2024 to USD 2.51 billion by 2032.
Ischemia reperfusion injury, also known as reperfusion injury or reoxygenation injury, occurs when blood supply returns to an ischemic area, leading to sudden tissue death. Instead of facilitating normal function in the cell, the restoration of oxygen and nutrients leads to inflammation and oxidative damage.
Ischemia-reperfusion injury is a major cause of multi-organ malfunction post a severe trauma with heavy bleeding. IRI occurrence may also lead to severe cardiac, pulmonary, spinal cord renal, hepatic and limb problems. Hence, the ischemia-reperfusion injury therapeutics market demand has increased.
Metformin, a plant-based anti-hyperglycemic drug having multiple mechanisms of action, has been a common ischemia reperfusion injury drug. It modulates ROS (reactive oxygen species) levels and oxidative damage during reperfusion, preventing organ malfunction. Focusing on kidney transplantation, Treprostinil (Remodulin) is another antihypertensive agent which is formulated as an injectable solution, also being considered for the treatment of ischemia-reperfusion injury.
With the emergence of nanotechnology in the medical field and a better understanding of cell interactions, scientists have diverted towards applying nanoparticle-mediated medicine. It can be considered an effective therapy owing to its enhanced drug accumulation, reduced systemic toxicity and improved pharmacokinetics. Numerous biomaterials like microneedles, liposomes, cardiac patches, and hydrogels are being explored as a potential tool for treatment. Given the substantial research efforts dedicated to this area, the ischemia-reperfusion injury therapeutics market value is estimated to rise significantly during the forecast period.
Market Breakup by Treatment Type
Market Breakup by Indications
Market Breakup by Route of Administration
Market Breakup by End User
Market Breakup by Distribution Channel
Market Breakup by Region– 7MM
Cardiovascular diseases continue to be some of the most chronic diseases worldwide, still affecting the lives of millions. Myocardial ischemia-reperfusion accounts for approximately 1.72% of deaths and disabilities in the global population. With the prevalence of cardiovascular, neurological, and kidney-related diseases, North America has held a significant part of the ischemia-reperfusion injury therapeutics market share in the historic period. A technologically advanced infrastructure, rising research and developments in medical care facilities and capital investments are key factors accountable for the market size.
The Asia Pacific region is expected to witness exponential growth in the coming years owing to the presence of a geriatric population that may lead to an increased incidence of chronic diseases like myocardial infarction. Moreover, the government initiatives to build technology-supportive infrastructure, an influx of foreign funds due to the easy availability of resources and the emergence of healthcare startups, can bring some substantial innovations in the ischemia reperfusion injury therapeutics market.
The key features of the market report include patent analysis, grants analysis, clinical trials analysis, funding and investment analysis, partnerships, and collaborations analysis by the leading key players. The major companies in the market are as follows:
REPORT FEATURES | DETAILS |
Base Year | 2023 |
Historical Period | 2017-2023 |
Forecast Period | 2024-2032 |
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Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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Breakup by Region-7MM |
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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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The market attained a value of about USD 1.67 billion in 2023, driven by incidence of chronic illnesses in an ageing population across the globe.
The market is anticipated to grow at a CAGR of 4.6% during the forecast period of 2024-2032, likely to reach a market value of USD 2.51 billion by 2032.
The growth of the market can be attributed to the pharmaceutical and technical advances in the therapeutics, owing to the prevalence of chronic cardiovascular, neurological, and kidney-related diseases, with an aim to prevent multi-organ malfunction that may occur due to IRI.
Nanoparticle-mediated medicine has emerged in the market to treat IRI. Several biomaterials like microneedles, liposomes, cardiac patches, and hydrogels are also being explored as a potential tool for treatment.
The major regions of the market include the United States, Japan, EU-4, and the United Kingdom.
The major treatment methods in the market include drug therapy and medicated gases, among others. Drug therapy is further categorised into antioxidants, anti-inflammatory agents, vasodilators, and immunomodulators, among others.
Heart, kidney, intestine, and other injuries are some of the key indications.
Major distribution channels include hospital pharmacies, retail pharmacies, and online pharmacies, among others.
The route of administration can be divided into oral, parenteral, topical or inhalation.
Major end users include hospitals, clinics, ambulatory surgical centres, and research institutes, among others.
Key players involved in the market are Pfizer Inc., AstraZeneca PLC, Novartis International AG, Merck & Co., Inc., Johnson & Johnson, Bayer AG, Sanofi SA, GlaxoSmithKline plc, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, AbbVie Inc., Amgen Inc., Gilead Sciences, Inc., F. Hoffmann-La Roche Ltd., Eli Lilly and Company, Takeda Pharmaceutical Company Limited, Biogen Inc., Regeneron Pharmaceuticals, Inc., Grifols, S.A., and Mitsubishi Tanabe Pharma Corporation.
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United States (Head Office)
30 North Gould Street, Sheridan, WY 82801
+1-415-325-5166
Australia
63 Fiona Drive, Tamworth, NSW
+61-448-061-727
India
C130 Sector 2 Noida, Uttar Pradesh 201301
+91-858-608-1494
Philippines
40th Floor, PBCom Tower, 6795 Ayala Avenue Cor V.A Rufino St. Makati City, 1226.
+63-287-899-028, +63-967-048-3306
United Kingdom
6 Gardner Place, Becketts Close, Feltham TW14 0BX, Greater London
+44-753-713-2163
Vietnam
193/26/4 St.no.6, Ward Binh Hung Hoa, Binh Tan District, Ho Chi Minh City
+84-865-399-124
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