The global bone void fillers market was valued at USD 3.64 Billion in 2025, driven by the rapidly rising incidence of osteoporosis, fractures, and bone tumors across the globe. The market is anticipated to grow at a CAGR of 6.80% during the forecast period of 2026-2035, with the values likely to reach USD 7.03 Billion by 2035.
Base Year
Historical Period
Forecast Period
FDA clearances and breakthrough designations are accelerating global adoption of advanced, resorbable bone void filler technologies.
Calcium phosphate’s superior biocompatibility and clinical versatility are reinforcing its dominance in orthopedic and spinal surgeries worldwide.
Asia Pacific’s fast-growing market, driven by surgical demand, may outpace others despite infrastructure and regulatory limitations.
Compound Annual Growth Rate
6.8%
Value in USD Billion
2026-2035
*this image is indicative*
Bone void fillers are biocompatible materials used to treat bone defects caused by trauma, surgery, or disease. Typically made from calcium phosphates, bioactive glass, or polymer composites, these fillers aid in bone regeneration and provide structural stability. Their importance is growing amid rising global fragility fractures, up to 37 million annually in those over 55, or 70 every minute . With one in three women and one in five men over 50 facing osteoporosis-related fractures, bone void fillers are vital in orthopedic, spinal, and dental surgeries where natural healing is insufficient. The market is anticipated to grow at a CAGR of 6.80% during the forecast period of 2026-2035.
FDA Approvals Fuel Innovation and Market Growth for Bone Void Fillers
Rising demand for synthetic alternatives and the need for predictable bone regeneration are accelerating product innovation in orthobiologics. For instance, in November 2024, Acuitive Technologies received FDA 510(k) clearance for CITREPORE, a synthetic bioactive bone void filler developed using its patented CITREGEN® biomaterial. This material supports metabolic bone healing by releasing citrate while being gradually resorbed and replaced by natural bone. The clearance is expected to drive market growth by expanding advanced, resorbable filler options for orthopedic and trauma care.
Focus on Using Innovative Biomaterials to Drive Bone Void Filler Market Demand
Increased clinical focus on minimally invasive surgery and next-generation biomaterials is shaping market demand for innovative fillers. For instance, in January 2024, the FDA granted Breakthrough Device Designation to OsStic®, a synthetic injectable bio-adhesive bone void filler by Biomimetic Innovations. This designation supports faster clinical validation and regulatory review. The recognition is poised to enhance global market development by encouraging early adoption of novel filler technologies that improve surgical outcomes and offer structural stability in complex fracture management.
Major market trends include surge in investments to develop effective products, rising FDA clearances, and collaborations between leading companies.
Growing FDA Approvals Expanding the Application of Bone Void Fillers
The global demand for synthetic bone grafts in spinal fusion is rising, with increasing preference for osteostimulative biomaterials. For instance, in November 2024, NovaBone Products received FDA clearance for its bioactive putty to be used in the intervertebral disc space alongside cleared interbody fusion devices. This extension of use strengthens NovaBone’s position in spinal applications and expands treatment possibilities. The development is expected to drive market growth by improving filler versatility and supporting a broader range of orthopedic and spinal procedures.
Increasing Fundings for Innovative Biomaterials to Boost Bone Void Fillers Market Value
The need for regenerative materials and supportive investments in orthopedic innovation is fostering market diversification. For instance, in August 2024, Serigen Mediproducts secured INR 10 crore from IAN Alpha Fund and Colossa Ventures to scale silk protein-based products. Its Serioss bone void filler and other scaffold innovations position Serigen as a pioneer in clinical-grade silk applications. With CDSCO approvals already in place, this funding and R&D progress will likely propel new product launches, enhancing the market’s value and competitive landscape in the forecast period.
Increasing Incidence of Spinal Fusion Surgeries to Fuel Bone Void Fillers Market Growth
Increasing spinal fusion procedures and demand for flexible biomaterials are shaping the global orthopedic landscape. For instance, in November 2023, Kuros Biosciences gained FDA clearance to use MagnetOs Flex Matrix in the interbody space across all spinal regions. With over 1.5 million spinal fusion procedures conducted annually in the U.S., the approval opens up high-volume surgical settings. The product’s unique structure promotes bone formation even in soft tissue, significantly boosting its clinical utility and expanding the bone void filler market footprint.
Rise in Collaborations to Meet Rising Bone Void Fillers Market Demand
Strategic partnerships and material advancements are reshaping bone filler portfolios in orthopedic care. For instance, in May 2022, Orthofix and MTF Biologics extended their partnership through 2032, including the launch of a new demineralized bone matrix (DBM) under the Legacy brand. This formulation, featuring cortical bone powder and a sodium hyaluronate carrier, will support spinal and orthopedic applications. The agreement is expected to bolster Orthofix’s offerings, strengthen distribution networks, and drive global market development through enhanced access to high-quality DBM products.
Calcium Phosphate to Lead the Market Segmentation by Type
Calcium phosphate is likely to dominate the bone void fillers market during the forecast period, driven by its superior osteoconductivity, biocompatibility, and structural similarity to natural bone. It is widely preferred in orthopedic and spinal surgeries, which supports its forecast CAGR of 6.8%. Demineralized bone matrix also sees strong growth with a 6.3% CAGR, owing to its biologically active components. This makes it especially useful for applications requiring enhanced healing, such as in spinal fusion procedures or complex fractures. As the demand for biologically active and customizable bone grafting solutions rises, DBM’s growth is fueled by its potential to significantly improve healing outcomes.
Calcium sulphate (5.3%) and collagen matrix (4.4%) follow with more specific applications. Calcium sulphate is typically favored for its resorbability and effective delivery of antibiotics, making it a key player in the treatment of bone infections or as a bone graft substitute. Collagen matrix products are known for their biodegradability and ability to support tissue regeneration, which is essential for applications that require soft tissue healing along with bone repair. Collagen’s natural ability to mimic the extracellular matrix promotes the formation of new tissues, making it particularly useful in surgeries where bone and soft tissue regeneration are needed simultaneously, such as in periodontal and dental procedures.
North America is expected to hold the largest share due to its high procedural volume in orthopedic and spinal surgeries, coupled with strong hospital adoption of synthetic graft alternatives. The region benefits from early access to FDA-cleared innovations and reimbursement support, driving sustained product uptake despite a 6.3% CAGR. Asia Pacific, though growing fastest at 6.6%, remains fragmented in infrastructure. Europe (5.9%) shows stable demand, especially in trauma care. Latin America (4.5%) and the Middle East and Africa (3.3%) lag due to limited advanced surgical access and slower regulatory pathways.
The key features of the market report comprise patent analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:
Founded in 1981 and headquartered in Naples, Florida, Arthrex Inc. is a global leader in minimally invasive orthopedic technology. The company specializes in surgical devices for sports medicine, orthobiologics, and trauma care. In the bone void fillers market, Arthrex offers bioresorbable calcium phosphate-based fillers designed to support bone healing in orthopedic and arthroscopic procedures. With a strong commitment to innovation, Arthrex continues to expand its biologics portfolio, enhancing patient recovery and surgical outcomes across orthopedic practices worldwide.
BONE SUPPORT AB, established in 1999 and headquartered in Lund, Sweden, is a specialty pharmaceutical company focused on bone regeneration. It is best known for its CERAMENT platform, a proprietary injectable bone void filler combining calcium sulfate and hydroxyapatite. CERAMENT is used in managing bone infections, trauma, and orthopedic surgeries. With regulatory approvals across Europe and the United States, BONE SUPPORT AB continues to grow its presence globally through clinical innovation and strategic partnerships in musculoskeletal care.
Stryker Corporation, founded in 1941 and headquartered in Kalamazoo, Michigan, is a global leader in medical technologies, including orthopedic and surgical innovations. Its bone void filler portfolio features products like Vitoss and HydroSet, designed to promote bone regeneration in trauma, spine, and joint surgeries. Stryker’s focus on R&D and integration of advanced biomaterials helps improve surgical precision and outcomes. Its strong hospital network and global distribution give it a competitive edge in expanding its orthobiologics market share.
Zimmer Biomet, established in 1927 and based in Warsaw, Indiana, is a prominent player in musculoskeletal healthcare. The company offers a wide range of orthopedic solutions, including bone void fillers such as OsseoFix and Puros. These are used in trauma, spine, and reconstructive surgeries to support bone healing and stability. Zimmer Biomet leverages decades of expertise and innovation in biomaterials to enhance surgical outcomes and is continually advancing patient care through integrated digital and biologics platforms.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other players in the market include Exactech, Inc., Baxter International Inc., Depuy Synthes (Johnson & Johnson Services, Inc.), Orthofix Medical Inc., and Globus Medical among others.
"Bone Void Fillers Market Report and Forecast 2026-2035" offers a detailed analysis of the market based on the following segments:
Market Breakup by Type
Market Breakup by Form
Market Breakup by End User
Market Breakup by Region
United States Bone Void Fillers Market
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Type |
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| Breakup by Form |
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| Breakup by End User |
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| Breakup by Region |
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| Supplier Landscape |
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