The global breast cancer therapeutics market is likely to be driven by rising incidents of breast cancer and advancements in treatment systems. North America, Asia and Europe are likely to be key markets.
Treatments of breast cancer include chemotherapy, surgery, and therapies such as hormonal, radiation and biological. Targeted drug therapy incorporates drugs that target proteins helping breast cancer cells develop, multiply, and live longer. Targeted drugs kill cancer cells or inhibit growth of cancer cells. Targeted drug therapy may be administered as IV, injection, or a pill. Specific targeted therapy drugs, such as monoclonal antibodies, act in multiple ways to regulate cancer cells; some monoclonal antibodies are also considered immunotherapy as these enhance the immune system.
In fifteen to twenty percent of breast cancers, HER2 (growth-enhancing protein) is produced in excess. Such cancers are called HER2-positive breast cancers and develop and multiply more forcefully than HER2-negative breast cancers. Various medicines have been developed to target the HER2 protein.
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HER2-targeted immunotherapy comprises monoclonal antibodies (that bind to the HER2 protein present on cancer cells) which inhibit cells growth. Examples include Trastuzumab (Herceptin and other brand names); Pertuzumab (Perjeta); combination of trastuzumab, pertuzumab, and hyaluronidase injection (Phesgo); and Margetuximab (Margenza). Antibody-drug conjugates refer to monoclonal antibodies linked to a chemotherapy medication. These include Fam-trastuzumab deruxtecan (Enhertu) and Ado-trastuzumab emtansine (Kadcyla).
HER2 is a protein type called a kinase which generally passes on signals (like directing the cell to grow). Drugs blocking kinases are known as kinase inhibitors, and include Lapatinib (Tykerb), Neratinib (Nerlynx), and Tucatinib (Tukysa).
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