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The Expert Market Research report, titled “Methylergonovine Manufacturing Plant Project Report 2025 Edition: Industry Trends, Capital Investment, Price Trends, Manufacturing Process, Raw Materials Requirement, Plant Setup, Operating Cost, and Revenue Statistics,” provides an in-depth and comprehensive examination of the financial and operational aspects of establishing methylergonovine plant.
The report is the result of extensive primary and secondary research, offering a detailed analysis of current market trends. It profiles key industry players, giving insights into their market strategies, production capacities, and financial performance, which are crucial for benchmarking and competitive analysis.
It delves into historical, current, and forecasted price trends, helping stakeholders understand market dynamics and price volatility. The report provides a thorough analysis of the mass balance and raw materials requirements, ensuring a clear understanding of the input-output ratios essential for efficient production. Detailed examinations of the various unit operations integral to the methylergonovine manufacturing process are included, highlighting process optimisation techniques and technological advancements.
The report presents a comprehensive capital cost analysis, detailing the financial investment required for setting up a methylergonovine plant. This includes an exhaustive breakdown of costs associated with raw materials, catchem, utilities, labour, packaging, transportation, land acquisition, construction, and machinery. Additionally, it offers an in-depth look at the operating costs, providing clarity on the recurring expenses involved in running the plant.
Projected profit margins and optimal product pricing strategies are outlined, offering guidance on maximising profitability. The report also addresses regulatory frameworks, environmental impacts, and sustainability measures pertinent to the methylergonovine industry.
Methylergonovine, sold under the brand name Methergine, is a medication used to prevent and control postpartum haemorrhage. It acts directly on the smooth muscle of the uterus, increasing tone, rate, and amplitude of rhythmic contractions. Methylergonovine is a derivative of the ergoline and lysergamide classes, structurally related to ergometrine and lysergic acid diethylamide. Methylergonovine was first synthesised in 1935 and introduced for medical use in 1943. It is also on the World Health Organisation's List of Essential Medicines.
Methylergonovine, also known as methylergometrine, is a semisynthetic ergot alkaloid used as an oxytocic in obstetrics and migraine treatment. It is a solid with a melting point of 172°C and a molecular weight of 335.4 g/mol. Methylergonovine is sparingly soluble in water (0.1 g/L at 25°C) but freely soluble in alcohol and acetone. It is available as 0.2 mg tablets, 0.2 mg/mL injections, and in 0.2 mg/mL liquid form. Methylergonovine is contraindicated in patients with hypertension and pre-eclampsia and can cause side effects such as nausea, vomiting, and dizziness in up to 10% of patients.
The process begins with obtaining the crude methylergonovine maleate product. This crude material is then melted and recrystallised, which offers advantages such as high stability, reproducibility, and ease of long-term storage. The next step is purification, where the crude product is dissolved in a mixture of methanol and ethanol, with activated charcoal added to remove impurities. The solution is then filtered while hot, and the filtrate is cooled to precipitate the purified methylergonovine maleate. Typical yields of this recrystallisation step range from 69-73%, with a purity of 99.87-99.88%.
The final step is formulation of the purified methylergonovine maleate into 0.2 mg tablets and a 0.2 mg/mL injectable solution. The tablets contain additional inactive ingredients such as acacia, lactose, and titanium dioxide, while the injectable solution includes maleic acid and sodium chloride. Through these careful manufacturing steps, a stable and high-quality methylergonovine maleate product is produced for use in obstetrics and migraine treatment.
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Methylergonovine is a derivative of ergometrine and can also be synthesised through a series of chemical reactions starting from lysergic acid. Below is a detailed description of the process:
1. Raw Materials
The primary raw materials used in the production of methylergonovine include:
2. Synthesis of Ergometrine
The process begins with the reaction of lysergic acid with dimethylamine and formaldehyde to form ergometrine.
Reaction: C16H16N2O2 + C2H7N + CH2O → C19H23N3O2
This reaction is typically carried out in the presence of a solvent like ethanol and an acid catalyst.
3. Methylation to Form Methylergonovine
Ergometrine is then subjected to methylation to form methylergonovine.
Reaction: C19H23N3O2 + CH3I → C20H25N3O2 + HI
This reaction involves the use of a methylating agent such as methyl iodide (CH3I).
4. Purification
The crude methylergonovine is purified through chromatography and is then dried and collected.
Methylergonovine, a semi-synthetic ergot alkaloid, is primarily used for the prevention and control of postpartum haemorrhage. It acts directly on the smooth muscle of the uterus, increasing tone, rate, and amplitude of rhythmic contractions. This induces a rapid and sustained uterotonic effect which shortens the third stage of labour and reduces blood loss. Methylergonovine is available in both injectable and oral forms. The injectable form is administered intravenously or intramuscularly by a doctor in a hospital setting, while the oral tablets are taken 3-4 times daily for up to 1 week after delivery. By promoting strong, sustained uterine contractions, methylergonovine helps expel the placenta and control excessive bleeding after childbirth or abortion. Rising number of childbirths and associated complications is increasing the demand for this alkaloid.
This production cost analysis report by Expert Market Research scrutinises the methylergonovine manufacturing process, offering a comprehensive overview necessary for stakeholders considering venturing into this sector. Based on the latest economic data, the report encompasses detailed insights into the primary process flow, raw material requirements, reactions involved, utility costs, operating costs, capital investments, pricing strategies, and profit margins. This report is an indispensable resource for entrepreneurs, investors, researchers, consultants, business strategists, and all those who have any kind of stake in the methylergonovine industry. It equips them with essential information and strategic insights to effectively navigate the complexities of the market.
The following sections detail the comprehensive scope of the prefeasibility report for a methylergonovine production plant:
This prefeasibility report aims to equip potential investors and existing manufacturers with crucial insights to make informed decisions in the methylergonovine industry.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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United States (Head Office)
30 North Gould Street, Sheridan, WY 82801
+1-415-325-5166
Australia
63 Fiona Drive, Tamworth, NSW
+61-448-061-727
India
C130 Sector 2 Noida, Uttar Pradesh 201301
+91-858-608-1494
Philippines
40th Floor, PBCom Tower, 6795 Ayala Avenue Cor V.A Rufino St. Makati City, 1226.
+63-287-899-028, +63-967-048-3306
United Kingdom
6 Gardner Place, Becketts Close, Feltham TW14 0BX, Greater London
+44-753-713-2163
Vietnam
193/26/4 St.no.6, Ward Binh Hung Hoa, Binh Tan District, Ho Chi Minh City
+84-865-399-124
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