Surgical site infections are considered one of the dangerous complications of surgical procedures, accounting for nearly 20% of all hospital-acquired infections (HAIs). They have a pooled prevalence of 2.5% to 41.9% worldwide and significantly affect low and middle-income countries, especially patients in intensive care units (ICU). The increasing cases of surgical site infections are augmenting the demand for preventive and therapeutic solutions. Moreover, the rise in antibiotic-resistant bacteria is propelling the need for alternative treatments, thereby driving innovation in the drug pipeline.
Major companies involved in the surgical site infection (SSI) treatment market include MinaPharm Pharmaceuticals, MB PHARMA s.r.o., and PolyPid Ltd., among others.
Leading drugs currently under the pipeline include D-PLEX and ActiveMatrix, among others.
Increasing investments in research and development of anti-infective drugs and the growing government funding for antimicrobial resistance solutions are poised to positively influence the surgical site infection (SSI) pipeline landscape.
The Surgical Site Infection (SSI) Drug Pipeline Insight Report by Expert Market Research gives comprehensive insights into surgical site infection (SSI) therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for surgical site infection (SSI). The surgical site infection (SSI) report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The surgical site infection (SSI) pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from the condition, and alignment with surgical site infection (SSI) treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to surgical site infection (SSI).
A surgical site infection (SSI) is a type of healthcare-associated infection (HAI) that occurs at the site of surgery. It exposes the patient to substantial healthcare costs as a result of severe morbidity and longer hospital stays along with the increased risk of death. Risk factors for surgical site infection include poor nutritional state, anemia, age, and obesity, among others.
Surgical site infection (SSI) therapeutics include broad-spectrum antibiotics and narrow-spectrum antibiotics targeting the specific pathogen identified through culture and sensitivity testing. Surgical site infection (SSI) emerging drugs like biologics, such as monoclonal antibodies, help in enhancing immune response and prevent infections. Further, the growing focus on non-antibiotic therapies, such as bacteriophage treatments and probiotic-based approaches, to address antibiotic resistance is anticipated to support the drug pipeline expansion in the coming years.
A 2023 systematic review and meta-analysis found the global incidence of surgical site infections (SSIs) to be 2.5%. Subgroup analysis showed an incidence of 2.7% by WHO region and 2.5% by the survey period. The African region reported the highest incidence of surgical site infections. Further, the pooled prevalence is estimated to be 2.5% to 41.9% worldwide.
This section of the report covers the analysis of surgical site infection (SSI) drug candidates based on several segmentations including:
By Phase
By Drug Class
By Route of Administration
The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase III covers a major share of the total clinical trials, with a substantial number of surgical site infection (SSI) drugs undergoing clinical development.
The drug molecule categories covered under the surgical site infection (SSI) pipeline analysis include small molecules, monoclonal antibodies (mAbs), peptides, antimicrobial agents, and other biologics. The surgical site infection (SSI) report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for surgical site infection (SSI).
The EMR report for the surgical site infection (SSI) drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed surgical site infection (SSI) therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. below is the list of a few players involved in surgical site infection (SSI) clinical trials:
Major drugs currently in the drug pipeline are as follows:
Sponsored by PolyPid Ltd., the objective of this randomized clinical trial is to investigate the efficacy and safety of the surgical site infection (SSI) drug candidate D-PLEX in the prevention of post-abdominal surgery incisional infection. The study is under Phase III clinical development and has an estimated 624 participants.
Baylor College of Medicine is conducting a Phase IV study aimed at examining the efficacy and safety of the investigational drug ActiveMatrix on spinal surgical site infection rate. The clinical trial has enrolled about 275 subjects and is expected to be completed by July 2026.
*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*
The Surgical Site Infection (SSI) Drug Report provides a strategic overview of the latest and future landscape of treatments for surgical site infection (SSI). It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into market trends, regulatory environments, and potential growth opportunities within surgical site infection (SSI) pipeline insights.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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