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Report Overview

Nephrotic syndrome is a kidney disorder characterized by excessive protein loss in urine, leading to swelling, low blood protein levels, and high cholesterol. It accounts for approximately 4.7 cases per 100,000 children worldwide. There is a significant unmet clinical need for more effective therapies, as current treatments like corticosteroids and immunosuppressive drugs have limitations and side effects. A growing focus on targeted therapies, including novel biologics and inhibitors, is expected to drive the pipeline's growth. The development of nephrotic syndrome drugs targeting specific molecular pathways offers hope for more personalized and effective treatments in the future.

  • Major companies involved in the nephrotic syndrome pipeline drugs market include Hoffmann-La Roche, SynAct Pharma Aps, and others.
  • Leading drugs currently in the pipeline include Obinutuzumab, 100 mg AP1189, and others.
  • Advancements in targeted therapies, a growing focus on biologics, and the need for more effective treatments addressing current limitations and unmet clinical needs are likely to positively impact the nephrotic syndrome drug pipeline.

Report Coverage

The Nephrotic Syndrome Drug Pipeline Insight Report by Expert Market Research gives comprehensive insights into nephrotic syndrome therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for nephrotic syndrome. The nephrotic syndrome report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The nephrotic syndrome pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with nephrotic syndrome treatment guidelines to ensure optimal care practices.

The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to nephrotic syndrome.

Nephrotic Syndrome Drug Pipeline Outlook

Nephrotic Syndrome is a kidney disorder characterized by excessive protein loss in urine, often due to damage to the glomeruli, which are tiny blood vessels in the kidneys. This condition leads to symptoms such as swelling (edema), low levels of blood protein (hypoalbuminemia), and high cholesterol.

The nephrotic syndrome treatment primarily focuses on reducing symptoms and preventing further kidney damage. Common treatments include corticosteroids to control inflammation, immunosuppressive drugs to reduce immune system activity, and angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to manage blood pressure and protect kidney function. However, there is an increasing need for more targeted therapies to improve efficacy, minimize side effects, and address the underlying causes of the condition.

Nephrotic Syndrome Epidemiology

Nephrotic Syndrome has an estimated worldwide incidence of 4.7 per 100,000 children. In the United Kingdom, approximately 10,000 people are affected by the condition. Diabetic nephropathy, a common cause, affects around 50 cases per million population in the United States. With limited treatment options, the growing focus on innovative therapies and biologics is expected to drive significant advancements in the drug pipeline.

Nephrotic Syndrome Drug Pipeline Therapeutic Assessment

This section of the report covers the analysis of nephrotic syndrome drug candidates based on several segmentations, including:

By Phase

  • Late-Stage Products (Phase 3 and Phase 4)
  • Mid-Stage Products (Phase 2)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

By Drug Class

  • Small Molecules
  • Monoclonal Antibodies
  • Gene Therapies
  • Peptides

By Route of Administration

  • Oral
  • Parenteral
  • Others

Nephrotic Syndrome – Pipeline Assessment Segmentation, By Phases

The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase III covers a major share of the total nephrotic syndrome clinical trials.

Nephrotic Syndrome – Pipeline Assessment Segmentation, By Drug Classes

The drug molecule categories covered under the nephrotic syndrome pipeline analysis include small molecules, monoclonal antibodies, gene therapies, and peptides. The nephrotic syndrome report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for nephrotic syndrome.

Nephrotic Syndrome Clinical Trials Therapeutic Assessment – Competitive Dynamics

The EMR report for the nephrotic syndrome drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed nephrotic syndrome therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in nephrotic syndrome clinical trials:

  • Hoffmann-La Roche
  • SynAct Pharma Aps
  • GlaxoSmithKline
  • LinkDoc Technology (Beijing) Co. Ltd.
  • Roche Pharma AG
  • Vertex Pharmaceuticals
  • Novartis
  • Biogen

Nephrotic Syndrome Emerging Drugs Profile

This section covers a detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for nephrotic syndrome. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of nephrotic syndrome drug candidates.

Drug: Huaiqihuang Granule, Prednisone, Levamisole

The Phase IV study, sponsored by Jianhua Zhou and conducted in collaboration with LinkDoc Technology, aims to compare the efficacy and safety of Prednisone combined with Huaiqihuang Granule against Prednisone combined with Levamisole for treating primary nephrotic syndrome in children. The study is expected to be completed by October 2025, enrolling approximately 402 participants.

Drug: Obinutuzumab

Hoffmann-La Roche is sponsoring a Phase III study, collaborates with clinical centers to evaluate the efficacy, safety, and pharmacokinetics of Obinutuzumab versus mycophenolate mofetil (MMF) in children and young adults with childhood-onset idiopathic nephrotic syndrome. The study, expected to be completed by August 2026, will enroll nearly 80 participants.

Drug: 100 mg AP1189

The Phase II study, sponsored by SynAct Pharma Aps, aims to assess the safety, tolerability, pharmacokinetics, and efficacy of AP1189 in patients with idiopathic membranous nephropathy (iMN) and severe proteinuria. The study will evaluate AP1189 as an add-on to ACE inhibitors or angiotensin II receptor blockers. It is expected to be completed by June 2026, with approximately 23 participants.

*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*

Reasons To Buy This Report

The Nephrotic Syndrome Drug Pipeline Insight Report provides a strategic overview of the latest and future landscape of treatments for nephrotic syndrome. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into nephrotic syndrome collaborations, regulatory environments, and potential growth opportunities.

Key Questions Answered in the Nephrotic Syndrome – Pipeline Insight Report

  • Which companies/institutions are leading the nephrotic syndrome drug development?
  • What is the efficacy and safety profile of nephrotic syndrome pipeline drugs?
  • Which company is leading the nephrotic syndrome pipeline development activities?
  • What is the current nephrotic syndrome commercial assessment?
  • What are the opportunities and challenges present in the nephrotic syndrome drug pipeline landscape?
  • What is the efficacy and safety profile of nephrotic syndrome pipeline drugs?
  • Which company is conducting major trials for nephrotic syndrome drugs?
  • Which companies/institutions are involved in nephrotic syndrome collaborations aimed at providing enhanced therapeutic alternatives for patients?
  • What are the geographies covered for clinical trials in nephrotic syndrome?

Related Reports

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Global Clinical Trials Market

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Scope of the Report

Details

Drug Pipeline by Clinical Trial Phase

  • Late-Stage Products (Phase III and Phase IV)
  • Mid-Stage Products (Phase II)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

Route of Administration

  • Oral
  • Parenteral
  • Others

Drug Classes

  • Small Molecules
  • Monoclonal Antibodies
  • Gene Therapies
  • Peptides

Leading Sponsors Covered

  • Hoffmann-La Roche
  • SynAct Pharma Aps
  • GlaxoSmithKline
  • LinkDoc Technology (Beijing) Co. Ltd.
  • Roche Pharma AG
  • Vertex Pharmaceuticals
  • Novartis
  • Biogen

Geographies Covered

  • North America
  • Europe
  • Asia Pacific
  • Others

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