Acute pyelonephritis is a bacterial infection of the kidneys, often arising from urinary tract infections. It accounts for around 10.5 million to 25.9 million cases globally each year. There is a significant unmet clinical need for better therapies, as current treatment options, such as antibiotics, often fail to address recurrent infections or antimicrobial resistance. The growing focus on developing novel antibiotics, immunotherapies, and targeted treatments is likely to support pipeline growth in the coming years. Advances in precision medicine and increased research funding are expected to drive innovation and improve treatment outcomes for this condition.
The Acute Pyelonephritis Drug Pipeline Insight Report by Expert Market Research gives comprehensive insights into acute pyelonephritis therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for acute pyelonephritis. The acute pyelonephritis report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The acute pyelonephritis pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with acute pyelonephritis treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to acute pyelonephritis.
Acute pyelonephritis is a bacterial infection of the kidneys, often caused by the ascending spread of bacteria from the urinary tract. It occurs primarily due to E. coli, although other pathogens can be involved. The disease is characterized by fever, flank pain, and dysuria. Early diagnosis and treatment are critical to preventing complications.
Acute pyelonephritis treatment is primarily done with antibiotics such as ciprofloxacin, trimethoprim-sulfamethoxazole, or ceftriaxone. In severe cases, intravenous antibiotics and hospitalization may be required. However, drug resistance and recurrence are challenges, leading to ongoing research for more effective and targeted therapies in the pipeline.
Pyelonephritis affects an estimated 10.5 million to 25.9 million individuals globally each year. In the United States, the incidence of acute pyelonephritis is 15 to 17 cases per 10,000 adults, with women representing 80% of cases. In Japan, urinary tract infection-related hospitalizations are 6.8 per 10,000 men and 12.4 per 10,000 women, with a 4.5% in-hospital mortality rate. Given the high burden and recurring infections, there is a critical need for more effective and innovative drug treatments.
This section of the report covers the analysis of acute pyelonephritis drug candidates based on several segmentations, including:
By Phase
By Drug Class
By Route of Administration
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase III covers a major share of the total acute pyelonephritis clinical trials.
The drug molecule categories covered under the acute pyelonephritis pipeline analysis include small molecules and biologics. The report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for Acute Pyelonephritis.
The EMR acute pyelonephritis drug report insights include the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in acute pyelonephritis clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for acute pyelonephritis. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of acute pyelonephritis drug candidates.
Sponsored by Spero Therapeutics, the objective of this Phase 3 study is to examine the efficacy of oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) compared to intravenous imipenem-cilastatin in participants with complicated urinary tract infections (cUTI) or acute pyelonephritis (AP). The study is expected to be completed by November 2025 and has an estimated 2,648 participants.
Sponsored by Jiangsu HengRui Medicine Co., Ltd., a Phase 3 clinical trial is underway to assess the efficacy and safety of HRS-8427 in treating adults with complicated urinary tract infections, including acute pyelonephritis. The study, with around 578 participants, is expected to be completed by November 2025, aiming to provide valuable insights into this potential treatment.
A Phase 2 study sponsored by Rempex (a subsidiary of Melinta Therapeutics, LLC) aims to evaluate the safety, tolerability, and pharmacokinetics of Meropenem-Vaborbactam in children aged 3 months to less than 12 years with complicated urinary tract infections, including acute pyelonephritis. The study is expected to be completed by July 2027, with nearly 66 participants.
*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*
The Acute Pyelonephritis Drug Pipeline Insight Report provides a strategic overview of the latest and future landscape of treatments for acute pyelonephritis. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into acute pyelonephritis collaborations, regulatory environments, and potential growth opportunities.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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Australia
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India
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+91-723-689-1189
Philippines
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+63-287-899-028, +63-967-048-3306
United Kingdom
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+44-753-713-2163
Vietnam
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+84-865-399-124
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